Endorphins Stimulation for Treating Pain


Endorphins can be used in the treatment of chronic joint rheumatism and migraine in patients in which there is too low or no endorphin level in the blood. USE/ADVANTAGE – The endorphins have an opiate type effect which regulates pain and are released if the pain rises above a certain level and inhibit the corresponding receptors of the nerve cells and interrupt the pain. Patients suffering from chronic joint rheumatism and migraine have no endorphins, or too low a level in the blood. Thus, administering endorphins alleviates the pain.


A small, handheld, microelectric, direct current generator with a low frequency modality is applied directly to a wound site through a composite wound covering or dressing. An electric potential difference is established between an anode and cathode of the composite wound dressing. Wound healing is facilitated by the biostimulatory effect of the applied microelectric current on adenosine triphosphate production (ATP), cell membrane transport of amino acids and protein synthesis. The microelectric currents applied through the composite wound dressing, promulgate antisepsis, interfere with the neurological transmission of pain signals and concomitantly stimulate the release of endorphins which helps to relieve the pain associated with wounds, ulcers and other tissue injuries.


A technique for inducing analgesic effects to relieve pain in a living organism whose central nervous system is associated with thermal receptors in the skin that sense heat and transmit signals through afferent fibers reflecting the intensity of the heat and its duration to the brain via the spinal cord. Applied to an area of the skin for a predetermined period is an air stream whose temperature is periodically elevated to create high-temperature pulses separated by lower temperature intervals whereby as a result of heat transfer from the skin area to tissue underlying the skin, the temperature at the surface of the skin is at a tolerable level. The signals transmitted to the brain during this period that reflect the sensed high temperature pulses stimulate the brain into producing endorphins having analgesic effects on the organism and relieving pain.


Conjugates are prepared from antinociceptive agents, particularly opioids or opioid analogs, more particularly dynorphins, endorphins, deltorphins, enkephalins or analogs thereof, by combining said antinociceptive agent with a material providing a functionally reactive group capable of reacting with a blood component (preferably a blood cell or protein). Said conjugates permit extension of the therapeutic life of the antinociceptive agent. They may be administered to patients to alleviate pain, produce analgesic effects, or assist in cases of narcotics withdrawal, and may also be used as probes for receptor activity. The administration to the patient may be made either in vivo or ex vivo and may be performed by either introducing the derivative including the reactive functional group into the patient’s vascular system or preparing such a conjugate externally (or in vitro) and introducing that conjugate to the patient’s vascular system.